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. 2021 Nov 7;13(1):1990827. doi: 10.1080/19490976.2021.1990827

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The components of the intestinal stem cell niche. The intestinal stem cell niche, which lies at the heart of gut epithelial renewal and regeneration, constitutes the factors contributed by four intestinal cellular compartments – the gut microbiota, the epithelium, immune cells of the underlying lamina propria and the mesenchymal cells. The gut microbiota regulates ISC physiology either directly or through other niche components, shaping the epithelial renewal during homeostasis and post-injury regeneration