Table 1.
Changes in the body weight of experimental rats in different phases of EAE.
| Body Weight (g) | |||
|---|---|---|---|
| Days Post Immunization (d.p.i.) | Control | EAE | EAE + Memantine |
| 0 | 194.0 ± 8.7 | 193.6 ± 10.4 | 195.9 ± 11.8 |
| 4 | 198.4 ± 10.8 | 190.4 ± 10.1 | 191.6 ± 9.1 |
| 12 | 210.7 ± 4.3 | 157.9 ± 9.9 *** | 166.0 ± 10.3 *** |
| 20 | 212.0 ± 3.3 | 163.2 ± 7.7 *** | 182.1 ± 5.1 ***,### |
| 25 | 211.8 ± 2.6 | 172.0 ± 12.9 *** | 188.4 ± 8.8 **,# |
The values represent the means ± SD from n = 64 animals.** p < 0.01, *** p < 0.001 significantly different vs. control. # p < 0.05, ### p < 0.01 vs. experimental autoimmune encephalomyelitis (EAE) rats not subjected to therapy (one-way ANOVA with post hoc Tukey’s test).