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. 2021 Oct 21;22(21):11355. doi: 10.3390/ijms222111355

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CA HIF-1α (pHIF-1α Mut B) ameliorates disc degeneration. (A) Representative T2 weighted micromagnetic resonance imaging (MRI) of rat tail in the four groups at 4 and 8 weeks. (B) Disc height index (DHI) of four groups at 4 and 8 weeks. ** p-value < 0.01, *** p-value < 0.005. (C) Histology and immunohistochemistry in puncture-induced rat IVD degeneration model. Histological analysis of intervertebral discs by Safranin O, H&E, Toluidine blue staining, and immunohistochemical staining of HIF-1α and collagen II in the nucleus pulposus (NP) in all groups. Scale bars represent 100 μm. ** p-value < 0.01, *** p-value < 0.005.