Figure 1.

Characterization of immune cell subsets in the tumor and stroma compartments at the invasive margin and core of the tumor of primary CRC. (a) Representative images of the multiplex staining with three immune panels; (b) scheme of the immune marker combinations used to define the subgroups of immune cells; (c) immune cell densities in Tumor and Stroma compartments in Central Tumor (CT) and Invasive Margin (IM) (boxes show median values and interquartile range, and numbers represent cell counts per mm², cube root transformed); and (d) illustration of the mean immune cell infiltration in tumor center in tumor and stromal compartment.