Table 3 |.

Novel associations between 8 distinct genomic loci and 11 serum metabolites in AASK that replicated in the ARIC Study

Chromosomal location	Mapped genes	Index SNP	Coded/reference allele	Coded allele frequency	Associated metabolite	Beta coefficient (P value) in AASK	Beta coefficient (P value) in the ARIC Studya
1:118887090-119887090	HAO2	rs7528838	T/A	0.252	2-Hydroxy-3-methylvalerate	−0.47 (1.03E–14)	−0.27 (5.97E–07)
2:73105659-74173773	ALMS1, ALMS1P, NAT8, TPRKB	rs13431529	C/G	0.535	N2-Acetyllysine	0.61 (3.26E–31)	0.62 (1.18E–45)
		rs6546854	G/A	0.547	N-Acetylleucine	0.53 (1.44E–21)	0.57 (1.39E–34)
		rs10168931	A/G	0.54	N-Acetylarginine	0.66 (1.13E–32)	0.68 (2.85E–49)
3:51489004-52620872	POC1A, ACY1, ABHD14A-ACY1	rs73835707	C/T	0.021	N-Acetylmethionine	1.38 (5.33E–13)	1.31 (7.12E–15)
8:143564265-144564265	OPLAH, CTD-3065J16.9, EXOSC4, GPAA1, KIAA1875, MAF1	rs59095288	C/T	0.309	6-Oxopiperidine-2-carboxylate	0.62 (1.92E–22)	0.50 (3.37E–24)
9:128422557-129422736	LRRC8A, PHYHD1, SH3GLB2	rs57294583	G/A	0.547	2′-O-Methylcytidine	0.39 (1.97E–12)	0.80 (6.88E–69)
11:48528971-49528971	PTPRJ, FOLH1	rs142514677	C/CAG	0.059	N-Acetyl-aspartyl-glutamate	−0.79 (5.35E–14)	−0.67 (1.57E–09)
11:67144985-68144985	ACY3, AP003385.2	rs115780269	T/C	0.025	N-Acetyltryptophan	1.64 (1.11E–22)	1.23 (1.72E–10)
		rs115780269	T/C	0.025	N-Acetyltyrosine	1.42 (4.15E–17)	1.24 (2.79E–10)
17:77706736-78706736	AFMID	rs114080902	T/C	0.043	N-Formylanthranilic acid	1.00 (1.80E–13)	0.89 (9.13E–15)

AASK, African American Study of Kidney Disease and Hypertension; ARIC, Atherosclerosis Risk in Communities; SNP, single-nucleotide polymorphism.

^aReplication analysis was performed in the ARIC Study for associations that were determined to be novel (see Tables 3 and 4 and Supplementary Tables S3 and S4 for details).