Table 5.
Cytotoxicity of natural substances expressed as a concentration that halves the viability of human cells (IC50). The data are presented as an average of 3 repetitions with SEM. The significance of the results was verified by ANOVA (Duncan’s post hoc test, p < 0.05).
| IC50 (µg/mL) | |||
|---|---|---|---|
| Cell Lines | NAC | RLs | UA |
| HRTEC | 1570 ± 70 b | 56.95 ± 0.65 d | 3.06 ± 0.17 g |
| HaCat | 4020 ± 470 a | 38.74 ± 4.96 de | 0.59 ± 0.14 h |
| HDF | 460 ± 20 c | 47.64 ± 2.43 de | 4.35 ± 0.41 f |
| HEK 293 | 1940 ± 250 b | 31.48 ± 4.31 e | 2.75 ± 0.22 g |
| HCAEC | 1830 ± 90 b | 27.50 ± 0.82 e | 0.03 ± 0.01 i |
Cell lines: primary human renal tubular epithelial cells (HRTEC), human keratinocytes (HaCat), human dermal fibroblasts (HDF), human epithelial kidney cells (HEK 293), and primary human coronary artery endothelial cells (HCAEC). Letters indicate statistically significant groupings. Groups that are statistically significantly different have different letters.