Figure 4.

This figure depicts some of the most common or novel chemically modified nucleotide analogues used in constructing splice modulating AOs. 2′-OMe: 2′-O-methyl; 2′-MOE: 2′-O-methoxyethyl; LNA: locked nucleic acid; ENA: 2′-O, 4′-C-ethylene-bridged nucleic acid; 2′-F: 2′-fluoro; CeNA: cyclohexenyl nucleic acid; ANA: altritol nucleic acid; HNA: 1,5-anhydro hexitol nucleic acid; MNA: morpholino nucleic acid; PS: phosphorothioate; PNA: peptide nucleic acid; PMO: phosphorodiamidate morpholino oligomer.