Table 3.
Differentially expressed proteins between MPN-DLBCL and R-DLBCL patients.
| Fold Change (MPN-DLBCL /R-DLBCL) |
Protein Name | Gene Name | p-Value | |
|---|---|---|---|---|
| Upregulated | 24.4 | Lactotransferrin * | LTF | 0.015 |
| 4.4 | Myeloblastin * | PRTN3 | 0.026 | |
| 1.6 | Endophilin-B1 | SH3GLB1 | 0.008 | |
| 1.6 | Alpha-1-antitrypsin | SERPINA1 | 0.017 | |
| 1.6 | ADP/ATP translocase 3 | SLC25A6 | 0.041 | |
| 1.5 | Mannose-1-phosphate guanyl transferase beta | GMPPB | 0.017 | |
| 1.5 | Echinoderm microtubule-associated protein-like 2 | EML2 | 0.028 | |
| 1.5 | Band 4.1-like protein 2 | EPB41L2 | 0.036 | |
| 1.4 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | GNB2 | 0.006 | |
| 1.4 | Deoxyribose-phosphate aldolase | DERA | 0.011 | |
| 1.3 | COMM domain-containing protein 10 | COMMD10 | 0.013 | |
| 1.3 | Neuroblast differentiation-associated protein AHNAK | AHNAK | 0.017 | |
| 1.3 | Glutathione synthetase | GSS | 0.027 | |
| 1.3 | Calpastatin | CAST | 0.029 | |
| 1.3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | GNB1 | 0.039 | |
| 1.3 | Annexin A2, Putative annexin A2-like protein |
ANXA2, ANXA2P2 | 0.045 | |
| Downregulated | 0.6 | Ribose-5-phosphate isomerase | RPIA | 0.010 |
| 0.6 | Replication protein A 14 kDa subunit | RPA3 | 0.013 | |
| 0.6 | 40S ribosomal protein S13 | RPS13 | 0.015 | |
| 0.6 | Rho guanine nucleotide exchange factor 1 | ARHGEF1 | 0.027 | |
| 0.6 | 40S ribosomal protein S19 | RPS19 | 0.027 | |
| 0.6 | 60S ribosomal protein L38 | RPL38 | 0.028 | |
| 0.6 | Glutaredoxin-3 | GLRX3 | 0.045 | |
| 0.7 | WD repeat-containing protein 61 | WDR61 | 0.006 | |
| 0.7 | 60S ribosomal protein L27a | RPL27A | 0.016 | |
| 0.7 | 60S ribosomal protein L24 | RPL24 | 0.026 | |
| 0.7 | 40S ribosomal protein S24 | RPS24 | 0.029 | |
| 0.7 | Rho guanine nucleotide exchange factor 2 | ARHGEF2 | 0.034 | |
| 0.7 | Purine nucleoside phosphorylase | PNP | 0.036 | |
| 0.8 | 60S ribosomal protein L9 | RPL9 | 0.026 | |
| 0.8 | 40S ribosomal protein S12 | RPS12 | 0.028 | |
| 0.8 | 40S ribosomal protein SA | RPSA | 0.032 | |
| 0.8 | Adenylosuccinate synthetase isozyme 2 | ADSS | 0.042 | |
| 0.8 | Zinc finger CCCH-type antiviral protein 1 | ZC3HAV1 | 0.044 |
A total of 34 proteins were identified as significantly differentially expressed between diagnostic lymphoma samples from MPN-DLBCL and R-DLBCL patients. * Protein expression evaluated by immunohistochemistry. Abbreviations: DLBCL, diffuse large B cell lymphoma; MPN, myeloproliferative neoplasia; R-, reference sample.