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. 2021 Oct 20;22(21):11338. doi: 10.3390/ijms222111338

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Structure of mitochondrial supercomplexes. The structure of the mitochondrial ridges is very important in the function of mitochondria and in particular in the stability of the super complex. Several proteins are involved in the stability of these ridges, the ATP synthase which will be at the top and the mitochondrial contact site and cristae organizing system (MICOS) which will be at the bottom. Between the two will be the super complexes. The two main super-complexes found in mammals I + III2 + IV1–4 and I + III2 are shown.