Table 2.

Results summary expressing magnitude of change compared to vehicle control. B = BEAS-2B, N = Naïve THP-1, A = Activated THP-1. Arrows indicate significant difference (p < 0.05) to control: low decrease (small down arrow), twofold or greater decrease (large down arrow), low increase (small up arrow), twofold or greater increase (large up arrow).

Flavoring	4 h																		6 h			24 h
Chemical	Viability			LDH			IL-1β			IL-6			IL-8			TNF-α			ROS			Viability			LDH			IL-1β			IL-6			IL-8			TNF-α
	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A	B	N	A
2,3,5-Trimethylpyrazine
2,3-Butanedione																		↓															🠓						🠓
2,3-Heptanedione												↓						↓	↑	🠑	🠑												↓						↓
2,3-Hexanedione												↓						↓	↑	↑	↑												↓						↓
2,3-Pentanedione												↓						↓	↑	↑	↑												↓						🠓
2-Acetylpyrazine
Acetaldehyde
Acetoin																																	🠓
Alpha-Pinene	🠓	🠓	🠓	↑			↑	↑	🠑		↑	↓			↓		↓	↓				↓	↓	↓		↑							↓			↓			↓
Benzyl alcohol
Butyraldehyde																		🠓																					🠓
Cinnamaldehyde									↓			↓			↓		↓	↓					↓	↓						↓			↓			↓			↓
Decanal		↓	↓	↑					↓			↓			↓		↓	↓				↓	↓	↓		↑				↓			↓			↓			↓
DL-Menthol
Ethyl Acetate
Ethyl Butyrate																		🠓														↑			↑				🠓
Ethyl Maltol									🠑								↑	🠑	🠑	🠑	🠑		🠓			↑	↑		↑	↑					↑			↑	↑
Eugenol	↓	↓	↓						↓			↓			↓		↓	↓				↓	↓	↓		↑	🠑			↓			↓			↓			↓
Furfural														🠑
Hexanal								↑				↓			↓			↓				🠓	↓	↓		↑			↑				↓		↑			↑	↓
Isoamyl Acetate																																	🠓
Isopropyl Myristate
L-Carvone									↓									↓												↓			↓						↓
Limonene		🠓						↑				↓			↓			↓					↓			↑							↓			↓			↓
Linalool												↓						↓															↓						🠓
Methyl Salicylate
Nonanal	↓	↓	↓	↑			↑		↓			↓			↓		↓	↓				↓	↓	↓		↑	↑			↓			↓			↓			↓
Propionaldehyde
Trans-2-Hexen-1-al	🠓								🠓			↓			↓		↓	↓				↓	🠓							↓			↓			↓			↓
Vanillin																		🠓	↑	↑	↑												🠓