Additional histology and electron microscopy. HE- and PAS-stained paraffin sections from (A,B) a non-FD control patient with hypertensive nephropathy, showing arteriosclerosis and chronic parenchymal damage with glomerulosclerosis (g), interstitial fibrosis and tubular atrophy, as well as (C,D) from a classical FD patient, showing vacuolated glomerular (*) and tubular (arrows) epithelial cells, in addition to signs of disease progression with global glomerulosclerosis (g). Electron microscopy (E,F) from the classical FD patient at ERT-naïve status showing FD-typical electron-dense multilamellar inclusion bodies (zebra bodies), which were pivotal for the diagnosis.