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. 2021 Nov 1;13(21):5500. doi: 10.3390/cancers13215500

Table 3.

Characteristics of the molecular subtypes using NanoStringnCounter analysis in the current study of 91 urothelial carcinoma (UC) samples.

Molecular Subtypes
(n, %)
Histological Subtypes
(n; %)
T Stage Category (n) High PD-L1 Expression (%) Survival Status, Median ±SD (Range), in Months
LUMINAL (65; 71%)
GATA3+ and/or KRT20+
Conventional UC
(55; 84.6%)
Ta (31);
T1 (21);
T2–T4 (3)
15 (27.3%) 49 ± 35.70 (12–125)
Variant histology UC
(10; 15.4%)
(Micropapillary (4); Nested (1); Plasmacytoid (1); Other Variants (4))
Ta (0);
T1 (6);
T2–T4 (4)
4 (40%) 45 ± 55.36 (4–119)
BASAL (19; 21%)
KRT5+ and/or KRT14+;
GATA3; KRT20
Conventional UC
(8; 42.1%)
Ta (3);
T1 (3);
T2–T4 (2)
4 (50%) 21 ± 7.34 (12–60)
Variant histology UC
(11; 57.9%)
(Micropapillary (2); Nested (4); Plasmacytoid (2); Other Variants (3))
Ta (0),
T1 (0);
T2–T4 (11)
8 (72.7%) 9.5 ± 21.42 (2–21)
NULL/DOUBLE NEGATIVE (7; 8%)
GATA3; KRT20;
KRT5; KRT14
Conventional UC
(4; 57.1%)
Ta (2);
T1 (0);
T2–T4 (2)
2 (66.7%) 32 ± 36.77 (6–58)
Variant histology UC
(3; 42.9%)
(Nested (1); Plasmacytoid (2))
Ta (0);
T1 (0);
T2–T4 (3)
3 (100%) 4 ± 1.15 (2–4)