Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Lancet Diabetes Endocrinol. 2021 May 27;9(7):436–445. doi: 10.1016/S2213-8587(21)00086-3

Figure 2. Changes in Psychomotor and Mental Efficiency during DCCT/EDIC at Specific Levels of A) Mean DCCT/EDIC HbA1c, B) Mean DCCT/EDIC Systolic Blood Pressure, C) Severe Hypoglycemia (Cumulative), and D) HbA1c, Systolic Blood Pressure, and Severe Hypoglycemia in Aggregate.

Figure 2.

Figure 2.

Figure 2.

Figure 2.

The bars represent the model-based estimates of the mean changes in psychomotor and mental efficiency between cognitive testing at DCCT baseline and each follow-up assessment, expressed as changes in z-scores and adjusted for age and sex at DCCT baseline and years of education as a time-dependent covariate. At each study year, the mean changes in z-scores and the slope for the association between HbA1c (or systolic blood pressure) and changes in z-scores are presented. There was a significant interaction between time and HbA1c (p=0·0003) as well as between time and systolic blood pressure (p<0·0001). There was no significant interaction between time and a history of severe hypoglycemia (p=0·45).