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. 2021 Oct 22;22(21):11395. doi: 10.3390/ijms222111395

Figure 4.

Figure 4

Brain inflammatory cytokines after hypoxic ischemic injury and MSC transplantation. Levels of inflammatory cytokines including interleukin (IL)-1α, IL-β, and IL-6, and tumor necrosis factor (TNF)-α in total brain tissue homogenates at 3 days after modeling. Data are expressed as mean ± standard error of the mean. * p < 0.05 compared to the HI + vehicle control, # p < 0.05 compared to the HI + naïve MSCs, $ p < 0.05 compared to HI + BDNF-eMSCs at dose 1 (approximately 1 × 104 cells), @ p < 0.05 compared to HI + BDNF-eMSCs at dose 2 (approximately 5 × 104 cells). Abbreviations: vehicle, HI + vehicle control, naïve MSCs; HI + naïve MSCs, BDNF MSC_dose1; HI + BDNF-eMSCs at 1 × 104 cells dose; BDNF MSC_dose2; HI + BDNF-eMSCs at 5 × 104 cells dose; BDNF MSC_dose3; HI + BDNF-eMSCs at 1 × 105 cells dose.