Table 2.

Summary of C-dots-based drug delivery systems reported as being capable of crossing the BBB. Polyethyleneimine (PEI); Transferrin (Trans); Doxorubicin (Dox); Dextrose (Dex); L-aspartic acid (L-Asp); Temozolomide (Temo); Epirubicin (Epi); Glycine (Gly); Fluorescein (Fluo); Tryptophan (Try); 1,2-ethylenediamine (EDA); Large Amino Acid-Mimicking (LAAM).

C-Dots	Size (nm)	Drug Loaded	Ligand Attached	In Vitro/In Vivo	Administration Mode	Refs.
C-dot/PEI	2.6	None	None	Primary rat microvascular endothelial cells and astrocytes	Medium	[145]
C-dot/Trans-Dox	2–6	doxorubicin	transferrin	SJGBM2 and CHLA266 (pediatric brain tumor cells)	Medium	[146]
C-dot/Dex-Asp	2.3–2.5	None	None	C6 glioma cells/mouse	Medium/i.v. in tail vein	[147,148]
C-dot/Trans	5		transferrin	Zebrafish		[135]
C-dot/Trans-Temo-Epi	2.6–3.5	Temozolomide epirubicin	transferrin	SJGBM2, CHLA266, CHLA200 (pediatric brain tumor cells) and U87 (adult glioblastoma cells)	Medium	[141]
C-dot/Gly	<5	None	None	C6 glioma cells/mouse	Medium/Medium/i.v. in tail vein	[149]
C-dot/Dex-Fluo	2.4–2.5	None	None	Zebrafish and rat	i.v. into the heart and i.v. in tail vein	[136]
C-dot/Try-ureaC-dot/Try-EDA	9.0–10.8	None	None	Zebrafish	i.v. into the heart	[150]
LAAMC-dots	2.5	None	None	Mouse	i.v. in tail vein	[151]