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EC50 values for cells cultured with 9b7 or aTNP-PNU ADCs. CI, confidence interval; EC50, the concentration required to achieve a 50% reduction of cell viability (μg/mL).
| ADC | ONE58, EC50 (95% CI) |
JL-1, EC50 (95% CI) |
H-Meso-1, EC50 (95% CI) |
143B +/+, EC50 (95% CI) |
143B -/-, EC50 (95% CI) |
|---|---|---|---|---|---|
| 9b7-PNU | 0.014 (0.011–0.016) | 0.055 (0.021–0.090) | 0.26 (0.174–0.339) | 0.012 (0.011–0.013) | 0.40 (0.233–0.558) |
| aTNP-PNU | 1.5 (0.749–2.212) | 1.1 (0.587–1.648) | 2.6 (1.842–3.370) | 0.33 (0.129–0.528) | - |
