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. 2021 Oct 26;22(21):11562. doi: 10.3390/ijms222111562

Figure 1.

Figure 1

Phenotypic characterization of Kp486 mutants resistant to recombinant depolymerase KP36gp50 versus the wild-type strain. (A) The spot test with KP36gp50 depolymerase (2.5 µg) and phages (KP36, KP34, KP27, and KP15) (5 × 105 PFU) on K. pneumoniae Kp7De mutant and its parental Kp486 strain. Lack of the translucent halo zones and clear plaques on the Kp7De lawn following spotting of depolymerase, and phages KP36 and KP34 respectively, indicate that Kp7De lost susceptibility to K63 capsule-targeting agents; (B) Antibiotic susceptibility profiles of Kp7De and Kp487 expressed as MIC (mg/L) (R-resistant and S-susceptible); (C) The fitness characteristics as proxied by the growth rate of Kp7De and Kp486 strains are shown in growth curves with the mean ± SEM of three independent experiments.