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. 2021 Nov 7;10(1):2052–2061. doi: 10.1080/22221751.2021.1997340

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Replication and lethality of H5N6 avian influenza viruses in BALB/c mice. (a) Virus titers in organs of mice inoculated intranasally with 10^6.0 EID₅₀ of different H5N6 viruses. Organs were collected on day 3 post-inoculation for virus titration in eggs. Data are means ± standard deviations (SD). The dashed lines indicate the lower limit of virus detection. The statistical analysis was conducted by using multiple t tests with GraphPad Prism 8 software. *, P<0.05 compared with the virus titers in the corresponding organs of rGD/330 virus-infected mice. **, P<0.01 compared with the virus titers in the corresponding organs of rGD/330 virus-infected mice. (b–g) MLD₅₀ for mice infected with each indicated virus.