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. 2021 Oct 28;22(21):11714. doi: 10.3390/ijms222111714

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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How exercise modulates tryptophan metabolism in skeletal muscle according to [38]. The kynurenine pathway of tryptophan degradation in skeletal muscle. Trp metabolites: Trp, Tryptophan; Kyn, Kynurenine; 3-HK, 3-Hydroxy-kynurenine; KynA, Kynurenic acid; AA, Anthranilic acid; QA, Quinolinic acid; Enzymes: TDO, Tryptophan 2,3-dioxygenase; IDO, Indoleamine 2,3-dioxygenase; KynU, Kynureninase; KATs, Kynurenine aminotransferases; KMO, Kynurenine 3-monooxygenase; LATs, large neutral amino acid transporters.