Table 3.

Pharmacokinetic profiles of pure UA50 and UA + PIP (50 + 20) combination.

Parameters	UA50	UA + PIP (50 + 20)
Cmax (µg/ml)	8.4 ± 0.53	10 ± 0.56*
Tmax (h)	1.7 ± 1.32	2.4 ± 1.67
Kel (1/h)	0.997 ± 0.23	0.076 ± 1.43**
T1/2ke (h)	0.63 ± 1.54	9.14 ± 1.85**
AUC0–t (µg/h/ml)	12.78 ± 2.59	125.15 ± 1.84**
cl (µl/h/mg)	0.65 ± 1.77	0.074 ± 0.35**
Vd (µl/g)	1.645 ± 1.12	0.95 ± 1.84**

Values are mean ± standard deviation (SD).

*p < .05; **p < .01 (significant with respect to UA 50 treated group).