Table 2.
Anti-inflammatory and antioxidant activity of the selected compounds.
| Analyte | Anti-Inflammatory Activity | Antioxidant Activity | ||
|---|---|---|---|---|
| COX-2 | HYAL | O2•− | FRAP | |
| IC50 (mM) a | IC50 (µM) a | SC50 (µM) b | mol Fe2+/mol c | |
| QU | 1.56 ± 0.05 E | 101.84 ± 6.09 F | 25.08 ± 0.69 E | 14.23 ± 0.18 G |
| MQ | 1.29 ± 0.05 C | 98.15 ± 4.41 E,F | 32.55 ± 2.19 G | 9.24 ± 0.06 E |
| DGQ | 1.44 ± 0.06 D | 98.08 ± 2.31 E | 18.00 ± 1.26 D | 6.39 ± 0.14 D |
| ECA | 1.62 ± 0.07 E | 81.85 ± 3.96 D | 7.89 ± 0.41 C | 10.39 ± 0.27 F |
| PB2 | 1.43 ± 0.06 D | 37.42 ± 1.78 B | 6.26 ± 0.09 B | 17.11 ± 0.06 I |
| CB1 | 1.56 ± 0.07 E | 37.69 ± 0.80 B | 5.31 ± 0.12 A | 16.30 ± 0.10 H |
| CHA | 2.86 ± 0.13 F | 80.69 ± 3.42 D | 19.73 ± 0.42 D | 9.06 ± 0.18 E |
| GT | 0.78 ± 0.03 B | 64.02 ± 2.87 C | 1012.00 ± 31.72 I | 0.29 ± 0.02 A |
| IND | 0.50 ± 0.02 A | 35.69 ± 5.34 A | - | - |
| DEX | 1.29 ± 0.04 C | 36.13 ± 2.68 A,B | - | - |
| TX | - | - | 540.33 ± 4.04 H | 2.98 ± 0.06 B |
| AA | - | - | 29.87 ± 0.51 F | 3.97 ± 0.02 C |
a IC50, half-maximal inhibitory concentration (amount of an analyte needed for 50% inhibition of enzyme activity); b SC50, half-maximal scavenging efficiency (amount of antioxidant needed to decrease the initial concentration of the oxidant by 50%); c antioxidant activity expressed in mol of ferrous ions (Fe2+) produced by 1 mol of an analyte. Analytes: QU, quercetin; MQ, miquelianin; DGQ, wintergreenoside A; ECA, (−)-epicatechin; PB2, procyanidin B2; CB1, cinnamtannin B-1; CHA, chlorogenic acid; GT, gaultherin. Positive controls: AA, ascorbic acid; DEX, dexamethasone; IND, indomethacin; TX, Trolox. Results presented as mean values ± SD (n = 3). For each parameter, different capital letters given in parentheses (A–I) indicate significant differences (p < 0.05).