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. 2021 Oct 28;22(21):11641. doi: 10.3390/ijms222111641

Figure 2.

Figure 2

Measurement of IFN-α and CDM-3008 anti-SARS-CoV-2 activity using SARS-CoV-2 subreplicon RNA-expressing Calu-3 cells. (A) Schematic of the experimental design of transfection with SARS-CoV-2 subreplicon RNA expression vector and treatments of IFN-α and CDM-3008 for 3 days prior to luciferase and cell viability assays. (B,C) SARS-CoV-2 subreplicon RNA-expressing Calu-3 cells were treated with 1–10,000 IU/mL IFN-α in B and 0.001-10 μM CDM-3008 in C for 1 day. Luciferase intensity (blue bars) and cell viability (orange lines) were measured and are shown as % of DMSO control. Error bars indicate SD (n = 3). * p < 0.05 and ** p < 0.01 (two-tailed t-test).