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. 2021 Oct 23;22(21):11437. doi: 10.3390/ijms222111437

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gross, histological and graphical representation of wound closure analysis of animal studies. (A) Macroscopic analysis and (B) H&E staining and immunostaining with CD34 marker of the wounds showing the healing of cutaneous wounds in 17 days when treated with 2dDR-loaded CS/Collagen hydrogels (n = 3). (C) Macroscopic analysis and (D) H&E staining and immunostaining with CD34 marker showing the healing of diabetic wounds in 20 days when treated with 2dDR-loaded alginate dressings (n = 4). Scale bars represent 100 µm. Results are presented as mean ± SD where *** p < 0.001, ^ϕϕϕ p < 0.001, ^ααα p < 0.001, ^ns p > 0.05 (not significant). Images, used in (A,B), are adapted from [29] with permission granted by Materials Today Communications, Copyright 2017 Elsevier. Images, used in (C,D), are adapted from [33] with permission granted by Journal of Biomaterials Applications, Copyright 2019 Sage Publications.