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. 2021 Oct 27;22(21):11609. doi: 10.3390/ijms222111609

Table 1.

Summary of tetraspanin functions in various virus life cycles.

Tetraspanin Virus Role of Tetraspanins In Virus’s Life Cycles
Viral Entry Replication Viral Exit
CD151 HPV [21,22] - -
IAV - [114] -
CD9 HPV [23] - -
HIV [55,56,57,65] - [79,86]
CoV [121,122,123,124,125,126] - -
CD63 HPV - [19,24] -
HIV [61,62,63,65,66] [63,72,73,74] [79,82,85]
Zika - - [100]
CoV [121,123,124] - -
CD81 HIV [55,56,58,59,60,65] [71] [65,78,79,81,86]
IAV [112] - [112]
CoV [121,122,123,124] - -
TSPAN7 HIV [50] - -

Abbreviations: CoV, coronavirus; HIV, human immunodeficiency virus; HPV, human papillomavirus; IAV, influenza A virus; ZIKV, Zika virus; CD9, cluster of differentiation 9; CD63, cluster of differentiation 63; CD81, cluster of differentiation 81; CD151, cluster of differentiation 151; TSPAN7, tetraspanin 7.