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. 2021 Oct 26;22(21):11565. doi: 10.3390/ijms222111565

Figure 3.

Figure 3

Chemical equation of dephosphorylation of a serine residue by an iron atom located in the CaN-active site adapted from Kissinger et al. (1995). A water molecule is deprotonated by the iron atom, followed by a hydrolysis reaction between the deprotonated (activated) water molecule and phosphorylated serine residue (phosphoserine). This reaction yields serine and phosphate. Threonine substrates follow a similar mechanism of water activation and dephosphorylation [16].