Table 2.
Formulation composition with their results used for optimization.
| Formulation code | PLGA (mg) |
PVA (%) |
Sonication time (min) |
Particle size (nm) |
Entrapment efficiency (%) |
|---|---|---|---|---|---|
| A | B | C | Y1 | Y2 | |
| F1 | 100 | 1 | 2.5 | 222.78 ± 3.83 | 38.16 ± 1.11 |
| F2 | 400 | 1 | 2.5 | 417.40 ± 5.23 | 76.51 ± 1.63 |
| F3 | 100 | 5 | 2.5 | 217.59 ± 2.22 | 61.52 ± 2.54 |
| F4 | 400 | 5 | 2.5 | 297.21 ± 2.45 | 82.49 ± 3.43 |
| F5 | 100 | 3 | 1 | 213.12 ± 1.55 | 52.34 ± 3.32 |
| F6 | 400 | 3 | 1 | 324.32 ± 2.03 | 77.94 ± 2.87 |
| F7 | 100 | 3 | 4 | 150.08 ± 1.77 | 53.27 ± 1.97 |
| F8 | 400 | 3 | 4 | 315.15 ± 2.66 | 87.04 ± 2.55 |
| F9 | 250 | 1 | 1 | 319.13 ± 4.17 | 60.38 ± 3.21 |
| F10 | 250 | 5 | 1 | 249.43 ± 3.43 | 74.99 ± 2.66 |
| F11 | 250 | 1 | 4 | 276.56 ± 1.98 | 65.44 ± 2.21 |
| F12 | 250 | 5 | 4 | 220.87 ± 2.65 | 80.16 ± 1.98 |
| *F13 | 250 | 3 | 2.5 | 267.21 ± 3.54 | 72.43 ± 3.11 |
| *F14 | 250 | 3 | 2.5 | 265.87 ± 3.11 | 71.23 ± 1.55 |
| *F15 | 250 | 3 | 2.5 | 263.45 ± 2.65 | 71.87 ± 1.65 |
*Center point having same composition.