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The protumoral effect of SIA-CIgG and TME-IgG causes an accelerated tumor outgrowth in vivo. Treatment with RP215, anti-human IgG antibody, or CIgG-shRNA, in contrast, reduces tumor growth rates in vivo. ab: antibody, PBS: phosphate buffered saline, CIgG: cancer-derived IgG, SIA-CIgG: sialylated CIgG, TME-IgG: IgG isolated from tumor microenvironment.
