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CIgG (blue) and its putative mode of action. CIgG is secreted by tumor cells and functions as an activator of integrin α6β4 on tumor cells (autocrine), siglecs on T cells, FcγRI on NK cells, and FcγRIIa on platelets (all paracrine). It drives tumorigenesis, immunosuppression, and platelet activation. Further, it impairs ADCC and phagocytosis. CIgG: cancer-derived IgG, NK cell: natural killer cell, ADCC: antibody-dependent cell-mediated cytotoxicity.
