Table 2.
Reactome pathway analysis performed upon a Zero-order human PPI network generated with the differentially expressed warfarin response data sets. False Discovery rate (FDR), enrichment ratio (Enrichment), negative log10 of enrichment probability multiplied by the enrichment ratio (Hybrid Score).
| Reactome Pathway | Total | Expected | Hits | p Value | FDR | Enrichment | Hybrid Score |
|---|---|---|---|---|---|---|---|
| Processing of DNA double-strand break ends | 3 | 0.0764 | 3 | 0.0000162 | 0.00134 | 39.26701571 | 188.1080492 |
| Molecules associated with elastic fibres | 38 | 0.968 | 10 | 2.24 × 10−8 | 0.0000104 | 10.33057851 | 79.02636345 |
| eNOS activation | 9 | 0.229 | 4 | 0.0000463 | 0.00265 | 17.46724891 | 75.7103757 |
| Muscle contraction | 52 | 1.32 | 11 | 5.16 × 10−8 | 0.0000145 | 8.333333333 | 60.72791915 |
| Elastic fibre formation | 45 | 1.15 | 10 | 0.00000013 | 0.0000273 | 8.695652174 | 59.87875346 |
| Homologous recombination repair of replication-independent double-strand breaks | 16 | 0.407 | 4 | 0.000581 | 0.0209 | 9.828009828 | 31.80170877 |
| Extracellular matrix organization | 157 | 4 | 17 | 0.000000397 | 0.0000618 | 4.25 | 27.20514035 |
| Cell surface interactions at the vascular wall | 99 | 2.52 | 11 | 0.0000382 | 0.00233 | 4.365079365 | 19.28464405 |
| Telomere Maintenance | 72 | 1.83 | 8 | 0.000447 | 0.017 | 4.371584699 | 14.64346438 |