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. 2021 Oct 22;22(21):11396. doi: 10.3390/ijms222111396

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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IL-8 expression significantly increased in the plasma and the monocytes of the OSA patients. Plasma was collected before and after the night PSG study, then submitted for monocyte isolation. (a) The levels of plasma IL-8 from each patient before and after the PSG study. (b) The difference in the plasma IL-8 levels before and after one night’s sleep was presented with ΔIL-8 which showed significant correlation with the severity of OSA (p = 0.003, r = 0.520). (c) The monocytes IL-8 mRNA expression was also found to be increased along the severity of the OSA patients’ condition. (d) The expression of the monocytes’ IL-8 mRNA was elevated with statistical significance comparing the expression before and after one night’s sleep (p = 0.044). Note: The data were presented as the means and the standard errors. Abbreviations: AHI = apnea–hypopnea index; IL = interleukin.