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. 2021 Oct 25;22(21):11480. doi: 10.3390/ijms222111480

Figure 3.

Figure 3

Interactions between ampicillin, imipenem, meropenem and the active site of OXA-48. (A) Modeling of ampicillin in the substrate pocket of OXA-48; ampicillin is depicted as blue stick. (B) Imipenem bound to OXA-48 in the substrate pocket (6P97); imipenem is depicted as orange stick. (C) Meropenem bound to OXA-48 in the substrate pocket (6P98); meropenem is depicted as yellow stick. Potential H-bonds between the residues of OXA-48 and carboxylate oxygens of the original β-lactam ring (orange) and that of the fused ring (black) are shown as dash lines.