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. 2021 Oct 30;22(21):11802. doi: 10.3390/ijms222111802

Figure 5.

Figure 5

Effects of ω-3 PUFA on PI(3)K/Akt signaling. (A) Representative Western blot of brain lysis: The brain of ω-3 PUFA orally administered IR-injured mice shows increased p-PI3K, p-PDK1, and p-Akt expression compared to IR-injured mice. (B) Representative Western blot of brain lysis: The brain of IR-injured Fat-1 mice showed increased p-PI3K, p-PDK1, and p-Akt expression, compared to that of IR-injured mice. * p < 0.001 vs. wt, # p < 0.001 vs. IR. Bar represents mean ± S.D. (wt, wild-type sham; ω-3 PUFA, ω-3 PUFA oral administration sham; Fat-1, Fat-1 induction sham; IR, IR renal injury in wild-type mice; ω-3+IR, IR renal injury in ω-3 PUFA oral administration mice; Fat-1+IR, IR renal injury in Fat-1 induction mice).