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. 2021 Oct 30;22(21):11802. doi: 10.3390/ijms222111802

Figure 6.

Figure 6

Effects of DHA and EPA on IS toxicity in HT22. (A) IS significantly decreased the cell survival in HT22 cells in a dose-dependent manner. (B) NAC increased the cell viability in IS-treated HT22 cells. DHA and EPA also increased the cell survival in IS-treated HT22 cells. (C) Representative Western blot: IS-treated HT22 cells decreased p-PI3K, p-PDK1, and p-Akt expression. DHA and EPA post-treatment increased p-PI3K, p-PDK1, and p-Akt expression in IS-treated HT22 cells. * p < 0.001 vs. control, # p < 0.001 vs. IS. Bar represents mean ± S.D. (IS, indoxyl sulfate; NAC, N-acetylcysteine; ET, ethanol; MT, methanol; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid).