Table 3.

commercially available systems for local antibiotic delivery to the affected sites of bones.

Carrier	Antimicrobial agent	Form	Commercial Products	Official Approval
PMMA	Gentamicin	Beads impregnated with the antibiotic	Palacos G®	FDA, 2003
	Tobramycin	Bone cement incorporating the antibiotic	Simplex P®	FDA, 2007
	Gentamicin and clindamycin	Bone cement incorporating the antibiotics	Copal® G + C	FDA, 2019
	Gentamicin and vancomycin	Bone cement incorporating the antibiotics	Copal® G + V	FDA, 2019
	Gentamicin	Beads impregnated with the antibiotic	Septopal®	The Therapeutic Goods Administration, Australia 2020
Hydroxyapatite	—	Xenograft granules that can be preloaded with suitable antibiotic	Endobon®	FDA, 2011
Hydoxyapatite/ Calcium sulfate	Gentamicin.	Synthetic bone substitute incorporated with the antibiotic	Cerament® G	Health Canada, 2018
Calcium sulfate	Tobramycin.	Bone graft substitute incorporating the antibiotic	Osteoset®	FDA, 2004
	—	Synthetic bone substitute that can be preloaded with suitable antibiotic.	Stimulan®	FDA, 2015
Calcium phosphate	—	Synthetic bone substitute that can be preloaded with suitable antibiotic.	Cerasorb® M	FDA, 2012
	—	Synthetic bone cement that can be preloaded with suitable antibiotic.	Biopex-R®	The Pharmaceutical and medical devices agency, Japan 2000
Calcium phosphate/ collagen	…	Synthetic bone substitute that can be preloaded with suitable antibiotic.	Cerasorb® Ortho Foam	FDA, 2020
Collagen	Gentamicin.	Matrix impregnated with the antibiotic	Collatamp®	Health Canada, 2008