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. 2021 Oct 28;22(21):11638. doi: 10.3390/ijms222111638

Figure 1.

Figure 1

CRP induces IL-23 production by human monocytes. (A) Human monocytes were either unstimulated or stimulated with different concentrations of CRP. Supernatants were analyzed after 24 h using ELISA. Representative example from one donor (mean + SEM of triplicate) of three experiments using three different donors. (B) Human monocytes were stimulated with CRP, TLR2 ligand Pam3CSK4, TLR3 ligand Poly I:C, TLR4 ligand LPS, TLR5 ligand flagellin, NOD2 ligand MDP, RLR ligand Poly I:C-HMW-LyoVec or CDS ligand Poly(dG:dC)/Lyovec. After 24 h, supernatants were analyzed by ELISA. Pooled data of three different donors. Each dot represents one donor. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ordinary one-way ANOVA, followed by Tukey’s multiple comparison test.