Table 1.

The top 10 most significantly changed proteins in cerebrospinal fluid of dogs with intervertebral disc herniation (IVDH) compared to healthy dogs. Complete list of all significantly changed proteins can be found in Supplementary File S2.

Higher in Abundance in IVDH Group (Upregulated)				Higher in Abundance in Control Group (Downregulated)
Accession No. (NCBI)	Adjusted p-Value	log2FC	Gene Symbol	Accession No. (NCBI)	Adjusted p-Value	log2FC	Gene Symbol
359321961	0.0147	0.31	F2	345789648	0.0056	−2.00	CHGB
73975389	0.0349	0.37	AFM	1418342647	0.0075	−1.82	SCG2
1239925760	0.0181	0.39	C5	345795204	0.0056	−1.81	SCG5
18139619	0.0181	0.41	PLG	3046976	0.0266	−1.58	COL1A1
1418515495	0.0181	0.43	AHSG	1239931864	0.0056	−1.43	ENPP2
2147092	0.0181	0.48	ALB	73970011	0.0181	−1.38	C10H2orf40
3915607	0.0266	0.50	APOA1	1418314244	0.0098	−1.31	TTR
1239918269	0.0056	0.52	AOC3	1239976444	0.0056	−1.30	FSTL1
73975797	0.0098	0.68	PON1	1418222978	0.0056	−1.30	CRSP2
1418304654	0.0349	1.01	APOC1	197085524	0.0056	−1.30	CRSP4