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. 2021 Oct 29;22(21):11765. doi: 10.3390/ijms222111765

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) TGFβ expression was not associated with FoxP3 expression in HCC tumor tissues. HCC tumor tissues from 18 patients were used. (b, upper) TGFβ, αSMA (ACTA2), and FoxP3 mRNA expression levels were not correlated in tumor samples from 34 HCC patients. GAPDH was used as housekeeping gene. (b, lower) TGFβ and αSMA expression was positively correlated in HCC tumor samples upon analysis of data available in public dataset GEPIA2 (http://gepia2.cancer-pku.cn/#correlation, accessed on 1 March 2021). (c) Analysis of correlation among the same 3 markers in 78 HCC tumor and paired peritumor specimens regarding the dataset GSE54236. In this latter analysis, peritumor mRNA expression values of each marker were subtracted from the matched tumor values for any patient to obtain net tumor expression indexes, as shown in the plots. This setting confirms a positive correlation between TGFβ1 and αSMA mRNA expression level and reveals an inverse correlation between TGFβ1 or αSMA and FoxP3.

(a) TGFβ expression was not associated with FoxP3 expression in HCC tumor tissues. HCC tumor tissues from 18 patients were used. (b, upper) TGFβ, αSMA (ACTA2), and FoxP3 mRNA expression levels were not correlated in tumor samples from 34 HCC patients. GAPDH was used as housekeeping gene. (b, lower) TGFβ and αSMA expression was positively correlated in HCC tumor samples upon analysis of data available in public dataset GEPIA2 (http://gepia2.cancer-pku.cn/#correlation, accessed on 1 March 2021). (c) Analysis of correlation among the same 3 markers in 78 HCC tumor and paired peritumor specimens regarding the dataset GSE54236. In this latter analysis, peritumor mRNA expression values of each marker were subtracted from the matched tumor values for any patient to obtain net tumor expression indexes, as shown in the plots. This setting confirms a positive correlation between TGFβ1 and αSMA mRNA expression level and reveals an inverse correlation between TGFβ1 or αSMA and FoxP3.