Table 3.
Comparison of clinical parameters between given variant carriers and sporadic MTC patients with no RET variant in the analysed regions. p-values for each analysis are shown.
| Analysed Parameter | e11 rs1799939 * |
e13 rs1800861 |
e14 rs1800862 * |
e15 rs1800863 * |
i14 rs2472737 |
|---|---|---|---|---|---|
| Age at diagnosis | 0.0682 | 0.0162 | 0.3687 | 0.1258 | 0.0809 |
| Disease stage at diagnosis | 0.6747 | 0.8680 | 0.9261 | 0.6055 | 0.5249 |
| Lymph node metastases | 0.5804 | 0.5879 | 1.0000 | 0.5804 | 1.0000 |
| Distant metastases | 1.0000 | 0.2445 | 1.0000 | 1.0000 | 1.0000 |
| Relapses | 0.7394 | 1.0000 | 0.5716 | 0.5761 | 1.0000 |
| Remission state | 0.5594 | 0.0879 | 0.1429 | 0.5594 | 0.1429 |
| CEA concentrations | 0.6879 | 0.8208 | 0.7656 | 0.6671 | 0.8345 |
| Ct/proCt | 0.5938 | 0.9511 | 0.3711 | 0.7595 | 0.4034 |
| TSH concentrations | 0.5934 | 0.1590 | 0.0736 | 0.8541 | 0.0216 |
* Some variants were not represented in an alone-standing setting. Therefore, e11 rs1799939 is represented by patients with this allele and e15 rs1800863; e15 rs1800863 is represented by patients with this allele only and patients with this allele together with e11 rs1799939; and e14 rs1800862 is represented by patients with this variant independently on the presence of other variants.