Figure 1.

Characteristics of wildtype (WT) and cyclic GMP–AMP synthase deficient (cGAS^-/-) mice after sham or cecal ligation and puncture (CLP), as indicated by survival analysis (A), serum endotoxin (B), cell free DNA (cfDNA) (C), peripheral blood leukocyte (total, neutrophils and lymphocytes) (D–F), renal function (blood urea nitrogen and serum creatinine) (G,H), alanine transaminase (I) and serum cytokines (TNF-α, IL-6 and IL-10) (J–L) (n = 12/group for (A) and n = 7–9/time-point or group for (B–L)).