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. 2021 Oct 23;22(21):11450. doi: 10.3390/ijms222111450

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Characteristics of macrophages from wildtype (WT) and cyclic GMP–AMP synthase deficient (cGAS^-/-) mice after an activation by media control, lipopolysaccharide (LPS), bacterial DNA (DNA) and LPS with DNA (LPS + DNA), as indicated by oxygen consumption rate (OCR) (as determined by mitochondrial stress test) and extracellular acidification rate (ECAR) (determined by glycolysis stress test) (A,B), along with the graph presentation of maximal respiration and maximal glycolysis (C,D), mitochondrial abundance (using mitochondrial DNA (mtDNA) and MitoTracker fluorescent staining) (E,F) and expression of PRKAA1 and PRKAA2 (mitochondrial promotors) (G,H). Independent triplicated experiments were performed.