Figure 2.

Schematic representation of Commander, ESCRT and Retromer complexes at the sorting endosome. Transmembrane cargoes are directed to plasma membrane, Golgi and Lysosome are accumulated in endosome. In this membrane-bound compartment, the Commander complex, together with the SNX and WASH complexes, mediates the sorting of cargoes to the plasma membrane. In parallel, ESCRT complexes recognize and direct ubiquitylated protein towards the lysosome for degradation. The Retromer complex, in association with the SNX and WASH complexes, defines transport towards both Golgi and the plasma membrane through the association of different SNX proteins.