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. 2021 Oct 29;22(21):11773. doi: 10.3390/ijms222111773

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the RABs-mediated recruitment of sorting machineries on the endosomal membrane. (Top) Recruitment of sorting machineries in function of RAB7. SNX and RAB7 recruitment on the membrane enriched in PtdIns(3)P that, in a sequential manner, mediate endosomal recycling. Activated RAB5 recruits Vps34 and induces PtdIns(3)P production, this event allows ESCRT0 to recognize ubiquitinated proteins on endosome membrane enriched in PtdIns(3)P and direct to lysosome for degradation.