Table 4.

Univariate and multivariate analyses of disease-free survival with clinicopathological parameters including NCAPH immunoreactivity in ER-positive breast cancer patients.

Variables	Univariate	Multivariate
	p-Value	Hazard Ratio	95% CI	p-Value
Age (≤50 vs. >50 years old)	0.186
Invasive tumor size (≤20 vs. >20 mm)	0.012	2.76	1.15–6.67	0.024
Lymph node status (+ vs. −)	0.014	2.22	0.95–5.19	0.066
Nuclear grade (1 vs. 2, 3)	0.007	2.15	0.85–5.44	0.105
PgR status (+ vs. −)	0.628
HER2 status (+ vs. −)	0.656
NCAPH IR (+ vs. −)	0.049	2.61	1.01–6.78	0.048

Note: Significant p-values are expressed in bold. Abbreviations: CI, confidence interval; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; IR, immunoreactivity; PgR, progesterone receptor.