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. 2021 Oct 25;22(21):11477. doi: 10.3390/ijms222111477

Figure 7.

Figure 7

Treatment with HAP particles reduced stroke infarct volume without overt increases in hemorrhagic transformation following MCAO. (A) Representative images of TTC staining of coronal brain sections from one mouse 72 h after MCAO. (B) Representative images of coronal brain sections from one mouse showing hemorrhage 72 h after MCAO. (C) Wild type C57BL/6J mice were subjected to MCAO and 3 h later treated i.v. with plasmin nano particles (HAP NP, 125 µg/kg), free plasmin (Ctl-Plasmin, 125 µg/kg), nano particle control (HA NP), or saline control or No treatment. (D) The volume of hemorrhage was quantified from serial brain sections 72 h after MCAO. n = 7–9 in each group, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. One-way ANOVA followed by Bonferroni post-hoc test for comparison of three or more groups was used.