Table 1.

The diverse roles of mechanosensitive mammalian ion channels.

Ion Channel Family	Mechanosensitive Forms	Examples of Physiological Relevance	References
ENaC	ASIC1	Gut mechanosensation	[60,61]
	ASIC2	Arterial baroreceptor reflex; cutaneous touch	[62,63]
	ASIC3	Gut mechanosensation; presure induced vasodilation; nociception	[60,61,64,65]
	βENaC	Myogenic vasoconstriciton	[66]
	γENaC	Myogenic vasoconstriciton	[66]
Piezo	Piezo 1	Vascular developmental/shear stress response; touch sensation; red blood cell function; bone growth; sensing bladder distension	[67,68,69,70,71,72]
	Piezo 2	Touch sensation; enterochromaffin response to mechanical signals	[73,74,75]
TREK	TREK1	Pain perception; mechanosensation in the gut; vasodilation	[76,77,78]
	TREK2	Pain perception	[79]
TRP	TRPA1	Touch sensation, pain perception	[80,81,82]
	TRPP1	Response to flow in renal epithelium; endothelial/epithelial cilia function	[83,84,85]
	TRPC6	Vascular smooth muscle contractiity (conflicting results)	[86,87,88]
	TRPP2	Response to flow in renal epithelium	[83]
	TRPV4	Sensing weight load during bone development; micturition reflex; pressure sensing	[89,90,91]
BK	BKCa	Mechanosensation in the gut; flow-induced K+ secretion in nephrons	[92,93]