Table 2.

Differentially methylated genes in Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinoma (MCC) tissues and/or MCPyV-positive MCC-derived cell lines.

Gene	Function	Promoter Methylation	Experimental Model	Reference
P14ARF	Tumor suppressor protein	Hypermethylated	MCPyV-positive/-negative MCC tissues	[115]
CDKN2A	Tumor suppressor protein	Hypermethylated	MCPyV-positive/-negative MCC tissues	[113]
RASSF1A	Tumor suppressor protein	Hypermethylated
RASSF2	Tumor suppressor protein	Hypermethylated	MCPyV-positive/-negative MCC tissues	[116]
RASSF5C	Tumor suppressor protein	Hypermethylated
RASSF10	Embryonic neurogenesis	Hypermethylated
RB1	Tumor suppressor protein	Hypermethylated	MCPyV-positive/-negative MCC tissues	[114]
MGMT	DNA repair and apoptosis	Hyper-/Hypomethylated	MCPyV-positive MCC cell lines	[117]
		Hypomethylated	MCC tissues *
PTCH1	HH receptor	Hypomethylated	MCPyV-positive/-negative MCC tissues	[118]
PD-1	Immune-inhibitory receptor	Hypomethylated	MCPyV-positive/-negative MCC tissues	[119]
Multiple genes		Hyper-/Hypomethylated	MCPyV-positive/-negative MCC tissues/cell lines	[120]
Multiple genes		Hyper-/Hypomethylated	MCPyV-positive/-negative MCC tissues/cell lines	[121]
KDM6B	H3K27 demethylation	Hypomethylated	MCPyV-positive tissues

* Unknown MCPyV positivity.