Figure 3.
Mitochondrial Complex I activity of C57BL/6 mice at 1 month post-irradiation exhibited a decrease in 16O- and 56Fe-irradiated mice livers as compared with the non-irradiated control. All slopes are significantly different (p < 0.0001) except for 28Si and non-irradiated (p = 0.5600) as well as 56Fe and 16O (p = 0.3964). At 2 months post-irradiation, similar decreases in 16O- and 56Fe-irradiated mice livers were observed as compared with the non-irradiated control. All slopes are significantly different (p = 0.0005 for 56Fe and 16O and p < 0.0001 for all others) except for 28Si- and non-irradiated (p = 0.9981) mice livers. At 4 months post-irradiation, a decrease was seen in 16O, 56Fe, 1 Gy gamma, and 3 Gy gamma as compared with the non-irradiated control. All slopes are significantly different (p < 0.0001). At 9 months post irradiation, a decrease was seen in all irradiation types as compared with the non-irradiated control except for 1 Gy gamma. All slopes are significantly different (p < 0.0001). At 12 months post-irradiation, a decrease was seen in all irradiation types as compared with the non-irradiated control. All slopes are significantly different (p = 0.0158 for 56Fe and 16O and p < 0.0001 for all others). All data points represent a group of n = 3 and correlate to the same animals from which the transcriptomic and proteomic data were generated.