Table 1.
Altered Transcripts and Proteins in the Mitochondria Dysfunction Pathway.
| Conditions with Mitochondria Dysfunction Pathway Effected | Number of Transcripts in the Pathway | Dysregulated Transcripts within Pathway | Number of Proteins in the Pathway | Dysregulated Proteins within Pathway |
|---|---|---|---|---|
| 1 mo 18O | 46 | aconitase 2, ATP synthase (H+ transporting mito F1 complex epsilon subunit, F1 subunit alpha beta & gamma, membrane subunit F, & peripheral stalk subunit OSCP), cytochrome c oxidase (subunit4I1, 6C, 7A2 like), carnitine palmitoyltransferase 1A, cytochrome c1, glutathione peroxidase 4, glutathione-disulfide reductase, cytochrome b, MTND2, NADH dehydrogenase subunits 4, 5 & 6 (complex I), NADH:ubiquinone oxidoreductase subunits A9, A10, A11, A13, B3, B4, B9, core subunit V1 & V2, pyruvate dehydrogenase E1 alpha 1 subunit, PTEN induced putative kinase 1, peroxiredoxin 3 & 5, succinate dehydrogenase complex iron sulfur subunit B, subunit C, & subunit D, superoxide dismutase 2, ubiquinol-cytochrome c reductase complex III subunit X, core protein 1, core protein 2 & Rieske iron-sulfur polypeptide 1, voltage dependent anion channel 1 & 2 | 8 | ATP synthase membrane subunit f, catalase, NADH dehydrogenase subunit 1 (complex I), NADH:ubiquinone oxidoreductase subunit V3, peroxiredoxin 3, synuclein alpha, SURF1 cytochrome c oxidase assembly factor, xanthine dehydrogenase |
| 1 mo 56Fe | 9 | ATP synthase F1 subunit gamma, carnitine palmitoyltransferase 1A, cytochrome b, NADH dehydrogenase subunit 1, 4, 5 & 6 (complex I), MTND2, NADH:ubiquinone oxidoreductase subunit B4 | 0 | |
| 1 mo 28Si | 3 | cytochrome b, MTND2, NADH dehydrogenase subunit 6 (complex I) | 6 | ATP synthase F1 subunit delta, catalase, mitogen-activated protein kinase 9, NADH dehydrogenase subunit 4(complex I), nicastrin, ras homolog family member T2 |
| 1 mo 3 Gy | 0 | 7 | ATP synthase membrane subunit f, catalase, NADH dehydrogenase subunit 1 (complex I), MTND2, NADH dehydrogenase subunit 4 (complex I), peroxiredoxin 3, synuclein alpha | |
| 2 mo 18O | 37 | ATP synthase (H+ transporting mito F1 complex epsilon subunit, F1 subunit alpha beta, gamma & delta, membrane subunit c locus 1 membrane subunit F & G, & peripheral stalk subunit OSCP & D), cytochrome c oxidase (subunit4I1, 6B1, 6C, 7B, & 8A), carnitine palmitoyltransferase 1A, cytochrome c1, glutathione peroxidase 4, glutathione-disulfide reductase, leucine rich repeat kinase 2, NADH dehydrogenase subunits 4 (complex I), NADH:ubiquinone oxidoreductase subunits A1, A2, A6, A8, A9, A10, A12, A13, B4, B7, B9, B11, S4, V3 core subunit S2 V1 & V2, oxoglutarate dehydrogenase, PTEN induced putative kinase 1, peroxiredoxin 3 & 5, parkin RBR E3 ubiquitin protein ligase, succinate dehydrogenase complex iron sulfur subunit B, subunit C, & subunit D, ubiquinol-cytochrome c reductase complex III subunit X, core protein 2 & Rieske iron-sulfur polypeptide 1, voltage dependent anion channel 1 | 10 | ATP synthase membrane subunit f, catalase, cytochrome c oxidase subunit 7A2 like, mitogen-activated protein kinase, kinase 4, mitogen-activated protein kinase 9, NADH:ubiquinone oxidoreductase subunit A11, NADH:ubiquinone oxidoreductase complex assembly factor 1, NADH:ubiquinone oxidoreductase subunit B6, peroxiredoxin 3, thioredoxin reductase 2 |
| 2 mo 56Fe | 19 | aph-1 homolog B gamma-secretase subunit, ATP synthase F1 subunit gamma, ATP synthase membrane subunit g, ATP synthase peripheral stalk subunit OSCP, cytochrome c oxidase copper chaperone COX17, cytochrome c oxidase subunit 4I1, cytochrome c oxidase subunit 6C, glutathione peroxidase 4, leucine rich repeat kinase 2, cytochrome b, NADH dehydrogenase subunit 4 (complex I), NADH:ubiquinone oxidoreductase subunits A1, A2, B2, B4, B9, & core subunit V2, synuclein alpha & ubiquinol-cytochrome c reductase binding protein | 0 | |
| 2 mo 3 Gy | 26 | ATP synthase (H+ transporting mito F1 complex epsilon subunit, F1 subunit gamma & delta, membrane subunit F & G, & peripheral stalk subunit OSCP), cytochrome c oxidase (subunit4I1, 6C, 7A2 like, & 8A), carnitine palmitoyltransferase 1A, cytochrome c1, glutathione peroxidase 4, glutathione-disulfide reductase, cytochrome b, NADH dehydrogenase subunits 1,4,5 &6 (complex I), MTND2, NADH:ubiquinone oxidoreductase subunits A2, A6, A9, A13, B2, B9, core subunit S2, S7 & V1, PTEN induced putative kinase 1, peroxiredoxin 5, parkin RBR E3 ubiquitin protein ligase, succinate dehydrogenase complex subunit C & D, ubiquinol-cytochrome c reductase complex III subunit X & XI & Rieske iron-sulfur polypeptide 1 | 0 | |
| 4 mo 18O | 11 | ATP synthase membrane subunit f, ATP synthase peripheral stalk subunit OSCP, cytochrome c oxidase subunit 5A & 6B1, NADH:ubiquinone oxidoreductase subunit A3, A7, A11, A12 & S6, thioredoxin 2, ubiquinol-cytochrome c reductase complex III subunit X | 0 | |
| 4 mo 3 Gy | 6 | cytochrome c oxidase subunit 5A & I, cytochrome b, MTND2, NADH dehydrogenase subunit 4 & 5 (complex I) | 0 | |
| 4 mo 1 Gy | 0 | 6 | caspase 8, NADH dehydrogenase subunit 4 (complex I), nicastrin, NADH:ubiquinone oxidoreductase subunit B6, NADH:ubiquinone oxidoreductase core subunit S3, thioredoxin reductase 2 | |
| 9 mo 18O | 12 | ATP synthase membrane subunit c locus 2, cytochrome c oxidase copper chaperone COX11, cytochrome c oxidase subunit 5A, glutathione peroxidase 4, cytochrome b, MTND2, NADH dehydrogenase subunit 4 & 5 (complex I), NADH:ubiquinone oxidoreductase subunit A8, A11, & S6, thioredoxin 2 | 0 | |
| 9 mo 3 Gy | 7 | cytochrome c oxidase copper chaperon COX11, cytochrome c oxidase subunit 1, MTND2, NADH dehydrogenase subunit 4 & 6 (complex 1), NADH:ubiquinone oxidoreductase subunit B4, ubiquinol-cytochrome c reductase binding protein | 0 | |
| 9 mo 28Si | 0 | 7 | caspase 3, cytochrome c oxidase subunit 7A2 like, mitogen-activated protein kinase 9, MTND2, NADH dehydrogenase subunit 4 (complex I), NADH:ubiquinone oxidoreductase core subunit S3, ras homolog family member T2 | |
| 12 mo 28Si | 0 | 6 | ATP synthase F1 subunit delta, catalase, cytochrome c oxidase subunit 6A1, MTND2, NADH:ubiquinone oxidoreductase complex assembly factor 2, ras homolog family member T2 | |
| 12 mo 1 Gy | 9 | cytochrome c oxidase subunit 7A2, 7A2 like, & 8A, fission mitochondrial 1, furin paired basic amino acid cleaving enzyme, NADH:ubiquinone oxidoreductase subunit B9, S6 & core subunit S2 | 11 | ATP synthase F1 subunit delta, catalase, cytochrome c oxidase assembly homolog COX15, cytochrome c oxidase subunit 7A2 like, mitogen-activated protein kinase 9, MTND2, NADH:ubiquinone oxidoreductase subunit A9, NADH:ubiquinone oxidoreductase complex assembly factor 1, NADH:ubiquinone oxidoreductase subunit B6, ras homolog family member T2, SURF1 cytochrome c oxidase assembly factor |