Figure 2.

Characteristic features of local low-cell inflammation in the renal corpuscles in diabetic kidney disease. Note: The typical initial changes in the renal corpuscles in diabetic kidney disease are the activation and proliferation of mesangial macrophages, thickening of GBM, a decrease in the number of podocytes, and the density of their processes. However, signs of canonical inflammation have not yet been expressed: there is no exudation (with deposition of fibrin and complement factors and significant migration of leukocytes into the intercapillary space of the renal glomeruli and the cavity of Bowman’s capsule.