Table 2.

Comparison of αSyn pathogenic progression induced during normal aging or by PQ exposure. αSyn pathogenic modifications in aged (40- to 60-day-old) or young PQ exposed flies (LT50 between 15- and 19-day-old) in flies expressing human αSyn (αSynWT or αSynA53T) under the ELAV driver.

Modifications (αSyn)	Aging-Induced	PQ-Induced
Accumulation	Yes (αSynWT, αSynA53T)	Yes (αSynWT, αSynA53T)
Serine 129 phosphorylation	Yes (αSynWT, αSynA53T)	Undetected or Yes (αSynWT) (αSynA53T)
Resistance to mild denaturating buffer	Undetected or Yes (αSynWT) (αSynA53T)	Yes (αSynWT, αSynA53T)
Masking of αSyn epitopes	Yes (αSynWT, αSynA53T)	Undetected (αSynWT, αSynA53T)
Resistance to PK digestion	Yes (αSynWT, αSynA53T)	Undetected (αSynWT, αSynA53T)